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<srw:recordPosition>10</srw:recordPosition><srw:recordData><mods xmlns="http://www.loc.gov/mods/v3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" version="3.5" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-5.xsd"><titleInfo><title>Individualized lesion-oriented test-bolus arterial-phase CT improves lesion enhancement and conspicuity in hepatocellular carcinoma</title></titleInfo><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/140064433X"><displayForm>Schmidt, Christian</displayForm><namePart type="given">Christian</namePart><namePart type="family">Schmidt</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Yüksel, Can</displayForm><namePart type="given">Can</namePart><namePart type="family">Yüksel</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Iwa, Roman</displayForm><namePart type="given">Roman</namePart><namePart type="family">Iwa</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Corban, Eric</displayForm><namePart type="given">Eric</namePart><namePart type="family">Corban</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Staudacher, Emona</displayForm><namePart type="given">Emona</namePart><namePart type="family">Staudacher</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Distelmaier, Martina</displayForm><namePart type="given">Martina</namePart><namePart type="family">Distelmaier</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Obeidi, Youssra</displayForm><namePart type="given">Youssra</namePart><namePart type="family">Obeidi</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Mesropyan, Narine</displayForm><namePart type="given">Narine</namePart><namePart type="family">Mesropyan</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Xie, Kunpeng</displayForm><namePart type="given">Kunpeng</namePart><namePart type="family">Xie</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Lemessa, Jonathan</displayForm><namePart type="given">Jonathan</namePart><namePart type="family">Lemessa</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal" authority="gnd" authorityURI="http://d-nb.info/gnd/" valueURI="http://d-nb.info/gnd/1304252728"><displayForm>Haag, Florian</displayForm><namePart type="given">Florian</namePart><namePart type="family">Haag</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Kuhl, Christiane</displayForm><namePart type="given">Christiane</namePart><namePart type="family">Kuhl</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Bruners, Philipp</displayForm><namePart type="given">Philipp</namePart><namePart type="family">Bruners</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><name type="personal"><displayForm>Barajas Ordonez, Felix</displayForm><namePart type="given">Felix</namePart><namePart type="family">Barajas Ordonez</namePart><role><roleTerm type="code" authority="marcrelator">aut</roleTerm><roleTerm type="text">VerfasserIn</roleTerm></role></name><typeOfResource>text</typeOfResource><originInfo><dateIssued encoding="w3cdtf" keyDate="yes">2026</dateIssued><dateIssued>July 2026</dateIssued></originInfo><language><languageTerm authority="iso639-2b" type="code">eng</languageTerm></language><physicalDescription><note>Illustrationen</note></physicalDescription><abstract type="scope">Background - Accurate arterial-phase timing in contrast-enhanced CT (CECT) is critical for evaluating hepatocellular carcinoma (HCC). Standard-delay methods may fail to capture peak arterial enhancement due to interindividual hemodynamic variability, potentially reducing lesion conspicuity. This study evaluated whether individualized, dynamically tailored arterial-phase CT (t-CT) based on test-bolus peak in the lesion or, if not feasible, within the portal vein, improves quantitative enhancement and lesion conspicuity compared with standard-delay CT (s-CT). - Materials and methods - This intraindividual study included 39 patients with 60 HCC lesions who underwent both t-CT and s-CT. Maximum and mean lesion attenuation (HUmax, HUmean), relative lesion-to-liver attenuation (relative HUmax, relative HUmean), and image noise were measured. Four readers rated lesion conspicuity on a five-point Likert scale; inter-reader agreement was assessed using weighted κ, Krippendorff’s α, and intraclass correlation coefficient (ICC). - Results - All quantitative parameters differed significantly between protocols. HUmax was greater in t-CT than on s-CT (151.0 [130.0-199.8] HU vs 113.5 [97.0-150.0]; p &lt; 0.001), as well as HUmean (124.5 [104.5-144.8] HU vs 90.5 [79.8-112.8]; p &lt; 0.001), relative HUmax (1.9 [1.7-2.3] vs 1.8 [1.5-2.2]; p = 0.009) and relative HUmean (1.6 [1.4-1.9] vs 1.4 [1.3-1.7]; p &lt; 0.001). Image noise was lower on t-CT than on s-CT (8.4 [6.7-9.7] vs 11.1 [9.6-12.9]; p &lt; 0.001). Median lesion conspicuity was higher on t-CT (4.0 vs 3.0; p &lt; 0.001). - Conclusion - Individualized lesion-oriented test bolus arterial-phase timing in CECT demonstrated higher lesion attenuation, greater lesion-to-liver contrast, lower image noise, and higher visibility compared with standard arterial-phase timing in HCC.</abstract><note type="statement of responsibility">Christian Schmidt, Can Yüksel, Roman Iwa, Eric Corban, Emona Staudacher, Martina Distelmaier, Youssra Obeidi, Narine Mesropyan, Kunpeng Xie, Jonathan Lemessa, Florian Haag, Christiane Kuhl, Philipp Bruners, Felix Barajas Ordonez</note><note>Online verfügbar: 15. April 2026, Artikelversion: 19. April 2026</note><note>Gesehen am 26.05.2026</note><subject><topic>Hepatocellular carcinoma</topic></subject><subject><topic>Image quality</topic></subject><subject><topic>Tomography</topic></subject><subject><topic>X-Ray computed</topic></subject><relatedItem type="host"><titleInfo><title>European journal of radiology</title></titleInfo><originInfo><place><placeTerm>Amsterdam [u.a.]</placeTerm></place><publisher>Elsevier Science</publisher><dateIssued>1990</dateIssued></originInfo><physicalDescription><note>Online-Ressource</note></physicalDescription><recordInfo><recordIdentifier source="bsz-sru-bbw-pica">32044483X</recordIdentifier></recordInfo></relatedItem><identifier type="kxp">1971551368</identifier><location><url displayLabel="Verlag" note="Kostenfrei zugänglich ohne Registrierung">https://doi.org/10.1016/j.ejrad.2026.112875</url></location><location><url displayLabel="Verlag" note="Kostenfrei zugänglich ohne Registrierung">https://www.sciencedirect.com/science/article/pii/S0720048X26002238</url></location><part order="200"><detail type="volume"><number>200</number></detail><extent unit="page"><start>1</start><end>8</end></extent></part><extension><vlz:externalType xmlns:vlz="http://visuallibrary.net/vlz/1.0/" recordSyntax="pica" code="Os"/><vlz:info xmlns:vlz="http://visuallibrary.net/vlz/1.0/" version="0"/></extension><recordInfo><recordCreationDate encoding="marc">26-05-26</recordCreationDate><recordChangeDate encoding="marc">26-05-26</recordChangeDate><recordIdentifier source="bsz-sru-bbw-pica">1971551368</recordIdentifier><descriptionStandard>rda</descriptionStandard></recordInfo></mods></srw:recordData></srw:record></srw:records>
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