naa a22 c 4500 1971551368 DE-627 20260526112018.0 cr uuu---uuuuu 260526s2026 xx |||||o 00| ||eng c 10.1016/j.ejrad.2026.112875 doi (DE-627)1971551368 (DE-599)KXP1971551368 DE-627 ger DE-627 rda eng Schmidt, Christian VerfasserIn (DE-588)140064433X (DE-627)1971551112 aut Individualized lesion-oriented test-bolus arterial-phase CT improves lesion enhancement and conspicuity in hepatocellular carcinoma Christian Schmidt, Can Yüksel, Roman Iwa, Eric Corban, Emona Staudacher, Martina Distelmaier, Youssra Obeidi, Narine Mesropyan, Kunpeng Xie, Jonathan Lemessa, Florian Haag, Christiane Kuhl, Philipp Bruners, Felix Barajas Ordonez July 2026 Illustrationen 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Online verfügbar: 15. April 2026, Artikelversion: 19. April 2026 Gesehen am 26.05.2026 Background - Accurate arterial-phase timing in contrast-enhanced CT (CECT) is critical for evaluating hepatocellular carcinoma (HCC). Standard-delay methods may fail to capture peak arterial enhancement due to interindividual hemodynamic variability, potentially reducing lesion conspicuity. This study evaluated whether individualized, dynamically tailored arterial-phase CT (t-CT) based on test-bolus peak in the lesion or, if not feasible, within the portal vein, improves quantitative enhancement and lesion conspicuity compared with standard-delay CT (s-CT). - Materials and methods - This intraindividual study included 39 patients with 60 HCC lesions who underwent both t-CT and s-CT. Maximum and mean lesion attenuation (HUmax, HUmean), relative lesion-to-liver attenuation (relative HUmax, relative HUmean), and image noise were measured. Four readers rated lesion conspicuity on a five-point Likert scale; inter-reader agreement was assessed using weighted κ, Krippendorff’s α, and intraclass correlation coefficient (ICC). - Results - All quantitative parameters differed significantly between protocols. HUmax was greater in t-CT than on s-CT (151.0 [130.0-199.8] HU vs 113.5 [97.0-150.0]; p < 0.001), as well as HUmean (124.5 [104.5-144.8] HU vs 90.5 [79.8-112.8]; p < 0.001), relative HUmax (1.9 [1.7-2.3] vs 1.8 [1.5-2.2]; p = 0.009) and relative HUmean (1.6 [1.4-1.9] vs 1.4 [1.3-1.7]; p < 0.001). Image noise was lower on t-CT than on s-CT (8.4 [6.7-9.7] vs 11.1 [9.6-12.9]; p < 0.001). Median lesion conspicuity was higher on t-CT (4.0 vs 3.0; p < 0.001). - Conclusion - Individualized lesion-oriented test bolus arterial-phase timing in CECT demonstrated higher lesion attenuation, greater lesion-to-liver contrast, lower image noise, and higher visibility compared with standard arterial-phase timing in HCC. Hepatocellular carcinoma Image quality Tomography X-Ray computed Yüksel, Can VerfasserIn aut Iwa, Roman VerfasserIn aut Corban, Eric VerfasserIn aut Staudacher, Emona VerfasserIn aut Distelmaier, Martina VerfasserIn aut Obeidi, Youssra VerfasserIn aut Mesropyan, Narine VerfasserIn aut Xie, Kunpeng VerfasserIn aut Lemessa, Jonathan VerfasserIn aut Haag, Florian VerfasserIn (DE-588)1304252728 (DE-627)1860419259 aut Kuhl, Christiane VerfasserIn aut Bruners, Philipp VerfasserIn aut Barajas Ordonez, Felix VerfasserIn aut Enthalten in European journal of radiology Amsterdam [u.a.] : Elsevier Science, 1990 200(2026), Artikel-ID 112875, Seite 1-8 Online-Ressource (DE-627)32044483X (DE-600)2005350-2 (DE-576)099718138 1872-7727 nnas volume:200 year:2026 elocationid:112875 pages:1-8 extent:8 https://doi.org/10.1016/j.ejrad.2026.112875 Verlag Resolving-System kostenfrei Volltext 0 https://www.sciencedirect.com/science/article/pii/S0720048X26002238 Verlag kostenfrei Volltext 0 AR 000 xxxxxcx a22 zn 4500 001 4970424233 003 DE-627 004 1971551368 005 20260526112018 008 260526||||||||||||||||ger||||||| 040 DE-16-250 DE-627 DE-16-250 689 s hd2026 689 s 1410508463 wissenschaftlicher Artikel (Zeitschrift) 689 s per_14 689 s s_8 689 p 1860419283 Haag, Florian 689 k 1416468056 Klinik für Radiologie und Nuklearmedizin 689 s 1410501914 Verfasser 689 s pos_11 852 DE-16-250 852 1 00 938 NG 938 33 939 2026-05-26 l01