2013 U HDHB:26-05-26 HDHB:26-05-26 11:20:18.000 HDHB:26-05-26 utf8 0 Osu Text txt Computermedien c Online-Ressource cr 1971551368 10.1016/j.ejrad.2026.112875 KXP 1971551368 eng rda 2026 July 2026 https://doi.org/10.1016/j.ejrad.2026.112875 H R Volltext LF 34 https://www.sciencedirect.com/science/article/pii/S0720048X26002238 H Volltext LF 34 Individualized lesion-oriented test-bolus arterial-phase CT improves lesion enhancement and conspicuity in hepatocellular carcinoma Christian Schmidt, Can Yüksel, Roman Iwa, Eric Corban, Emona Staudacher, Martina Distelmaier, Youssra Obeidi, Narine Mesropyan, Kunpeng Xie, Jonathan Lemessa, Florian Haag, Christiane Kuhl, Philipp Bruners, Felix Barajas Ordonez 1971551112 Tpv3 gnd/140064433X piz Schmidt Christian VerfasserIn aut Can Yüksel VerfasserIn aut Roman Iwa VerfasserIn aut Eric Corban VerfasserIn aut Emona Staudacher VerfasserIn aut Martina Distelmaier VerfasserIn aut Youssra Obeidi VerfasserIn aut Narine Mesropyan VerfasserIn aut Kunpeng Xie VerfasserIn aut Jonathan Lemessa VerfasserIn aut 1860419259 Tpv3 gnd/1304252728 piz Haag Florian VerfasserIn aut Christiane Kuhl VerfasserIn aut Philipp Bruners VerfasserIn aut Felix Barajas Ordonez VerfasserIn aut 200 2026 112875 1-8 8 Illustrationen Online verfügbar: 15. April 2026, Artikelversion: 19. April 2026 Gesehen am 26.05.2026 Enthalten in 32044483X Obv zdb/2005350-2 099718138 1872-7727 European journal of radiology Amsterdam [u.a.] Elsevier Science 1990 Online-Ressource 202600002000000999 s Hepatocellular carcinoma s Image quality s Tomography s X-Ray computed Alle Personen wegen Universitätsbibliographie Heidelberg bitte stehen lassen! HDHB/26.05.2026 Background - Accurate arterial-phase timing in contrast-enhanced CT (CECT) is critical for evaluating hepatocellular carcinoma (HCC). Standard-delay methods may fail to capture peak arterial enhancement due to interindividual hemodynamic variability, potentially reducing lesion conspicuity. This study evaluated whether individualized, dynamically tailored arterial-phase CT (t-CT) based on test-bolus peak in the lesion or, if not feasible, within the portal vein, improves quantitative enhancement and lesion conspicuity compared with standard-delay CT (s-CT). - Materials and methods - This intraindividual study included 39 patients with 60 HCC lesions who underwent both t-CT and s-CT. Maximum and mean lesion attenuation (HUmax, HUmean), relative lesion-to-liver attenuation (relative HUmax, relative HUmean), and image noise were measured. Four readers rated lesion conspicuity on a five-point Likert scale; inter-reader agreement was assessed using weighted κ, Krippendorff’s α, and intraclass correlation coefficient (ICC). - Results - All quantitative parameters differed significantly between protocols. HUmax was greater in t-CT than on s-CT (151.0 [130.0-199.8] HU vs 113.5 [97.0-150.0]; p < 0.001), as well as HUmean (124.5 [104.5-144.8] HU vs 90.5 [79.8-112.8]; p < 0.001), relative HUmax (1.9 [1.7-2.3] vs 1.8 [1.5-2.2]; p = 0.009) and relative HUmean (1.6 [1.4-1.9] vs 1.4 [1.3-1.7]; p < 0.001). Image noise was lower on t-CT than on s-CT (8.4 [6.7-9.7] vs 11.1 [9.6-12.9]; p < 0.001). Median lesion conspicuity was higher on t-CT (4.0 vs 3.0; p < 0.001). - Conclusion - Individualized lesion-oriented test bolus arterial-phase timing in CECT demonstrated higher lesion attenuation, greater lesion-to-liver contrast, lower image noise, and higher visibility compared with standard arterial-phase timing in HCC. 2013 PICA 26-05-26 26-05-26 11:20:18.000 HDHB:26-05-26 utf8 4970424233 26-05-26 l01 16/250 00 NG 14 s hd2026 00 s 1410508463 Tdi 340508469 wissenschaftlicher Artikel (Zeitschrift) 01 s per_14 02 s s_8 03 p 1860419283 Tdx Haag Florian 04 k 1416468056 Tdi 346468051 Klinik für Radiologie und Nuklearmedizin 04 s 1410501914 Tdi 34050191X Verfasser 04 s pos_11 04 33